Determination of N-nitrosodimethylamine in environmental aqueous samples by isotope-dilution GC/MS-SIM

Citation
A. Raksit et S. Johri, Determination of N-nitrosodimethylamine in environmental aqueous samples by isotope-dilution GC/MS-SIM, J AOAC INT, 84(5), 2001, pp. 1413-1419
Citations number
19
Categorie Soggetti
Agricultural Chemistry
Journal title
JOURNAL OF AOAC INTERNATIONAL
ISSN journal
10603271 → ACNP
Volume
84
Issue
5
Year of publication
2001
Pages
1413 - 1419
Database
ISI
SICI code
1060-3271(200109/10)84:5<1413:DONIEA>2.0.ZU;2-V
Abstract
An analytical method for the determination of N-nitrosodimethylamine (N-NDM A) in environmental aqueous samples has been developed using isotope diluti on gas chromatography/mass spectrometry in the selected ion monitoring mode (GUMS-SIM). After deuterated N-nitrosodimethylamine (d(6)-N-NDMA) as surro gate standard was added to the samples, the analytes were extracted with me thylene chloride, dried with anhydrous sodium sulfate, and concentrated in a rotary evaporator. The concentrated extracts were analyzed by GC/MS-SIM a fter adding N-nitrosodiethylamine as an internal standard. The method detec tion limit for N-NDMA was 0.003 pg/muL and was validated by an analysis of a fortified water sample. The method was applied to real samples.