Rapid carbohydrate protecting group manipulations assisted by microwave dielectric heating

Citation
E. Soderberg et al., Rapid carbohydrate protecting group manipulations assisted by microwave dielectric heating, J CARB CHEM, 20(5), 2001, pp. 397-410
Citations number
56
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF CARBOHYDRATE CHEMISTRY
ISSN journal
07328303 → ACNP
Volume
20
Issue
5
Year of publication
2001
Pages
397 - 410
Database
ISI
SICI code
0732-8303(2001)20:5<397:RCPGMA>2.0.ZU;2-N
Abstract
The protocols for oligosaccharide synthesis are often tedious due to extend ed synthetic routes and reaction times. We herein describe methods assisted by microwave dielectric heating, which enable very short reaction times an d high yields for the introduction and removal of eleven of the most common ly used protecting groups in carbohydrate syntheses. Several examples are r eported, where solid supported reagents in combination with microwave diele ctric heating have been used. This results in both faster and easier synthe sis and purification.