E. Caussinus et al., Simultaneous occurrence of Epstein-Barr virus associated Hodgkin's diseaseand HHV-8 related multicentric Castleman's disease: a fortuitous event?, J CLIN PATH, 54(10), 2001, pp. 790-791
Citations number
10
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Previous serological or molecular studies by means of the polymerase chain
reaction have failed to show an association between classic Hodgkin's disea
se (HD) and human herpesvirus 8 (HHV-8). Using immunohistochemistry, this s
tudy reexamines (with anti-LNA1 antibody) the possible association of HHV-8
with HD, particularly in human immunodeficiency virus (HIV) infected patie
nts. HHV-8 was not detected in the Reed Sternberg cells of the cases examin
ed (33 HIV negative and 17 HIV positive), thus confirming the lack of invol
vement of HHV-8 in HD. Interestingly, a case of HHV-8 positive multicentric
Castleman's disease was associated with Epstein-Barr virus positive HD in
the same lymph node, which was probably a fortuitous occurrence.