INHIBITION OF LIPID-SYNTHESIS OF BACTERIA, YEAST AND ANIMAL-CELLS BY ANACARDIC ACIDS, GLYCEROL-3-PHOSPHATE DEHYDROGENASE INHIBITORS FROM GINKGO

Authors
MURATA M IRIE J HOMMA S
Citation
M. Murata et al., INHIBITION OF LIPID-SYNTHESIS OF BACTERIA, YEAST AND ANIMAL-CELLS BY ANACARDIC ACIDS, GLYCEROL-3-PHOSPHATE DEHYDROGENASE INHIBITORS FROM GINKGO, Lebensmittel-Wissenschaft + Technologie, 30(5), 1997, pp. 458-463
Citations number
15
Categorie Soggetti
Food Science & Tenology
Journal title
Lebensmittel-Wissenschaft + Technologie → ACNP
ISSN journal
00236438
Volume
30
Issue
5
Year of publication
1997
Pages
458 - 463
Database
ISI
SICI code
0023-6438(1997)30:5<458:IOLOBY>2.0.ZU;2-R
Abstract
The effects of anacardic acids (Anal, glycerol-3-phosphate dehydrogena se (GPDH) inhibitors from ginkgo on growth and lipid synthesis of Baci llus subtilis, Lipomyces starkeyi and 3T3-L1 cells were examined. Ana inhibited growth of B. subtilis, and the inhibition was reversed by ph osphatidic acid or monoacylglycerol. Ana-a (100 mu g/mL) inhibited lip id accumulation in L. starkeyi but not growth, when it was added after 40 h of incubation. Ana did not inhibit the adipose conversion of 3T3 -L1 cells, as their inhibitory activity against GPDH of the cells was weak.