Adverse reactions caused by benzodiazepines rarely occur. We present a case
of a 70-year-old man who developed a maculopapular exanthema after the ing
estion of tetrazepam. For his diagnosis, skin tests were performed, includi
ng prick and patch tests, not only with the benzodiazepine implicated in th
e reaction, but also with benzodiazepines of other groups. Single-blind ora
l challenge tests were also performed in the patient, in order to assess hi
s tolerance to other benzodiazepines.