The application of topological indexes for prediction of the R-m values for tocopherols in RP-TLC

alpha-, beta-, gamma- and delta -tocopherols have been separated by reverse d phase thin layer chromatography using seven different mobile phases. The R-M values of the compounds have been correlated with the numerical values of the topological indexes, the sum of the net electron charge (Sigma NEC) on the tocopherols' -C-O-H groups, the moment dipoles (mu (mph)), and the p ermitivities (epsilon (mph)) of the mobile phases. Most accurate prediction of the R-M values of the tocopherols in all the mobile phases investigated , were achieved by use of two parametric equations employing the dipole mom ents of the mobile phases, and one topological index from among the topolog ical indexes (2)chi (v), B-0, C, or the sum of the net electron charge (Sig ma NEC).