Enantiomeric separation of some clinically used racemic drugs on Pirkle-1Jchiral stationary phase

Authors
Chilmonczyk, Z Ksycinska, H Aboul-Enein, HY Lee, WJ
Citation
Z. Chilmonczyk et al., Enantiomeric separation of some clinically used racemic drugs on Pirkle-1Jchiral stationary phase, J LIQ CHR R, 24(16), 2001, pp. 2505-2512
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
ISSN journal
10826076 → ACNP
Volume
24
Issue
16
Year of publication
2001
Pages
2505 - 2512
Database
ISI
SICI code
1082-6076(2001)24:16<2505:ESOSCU>2.0.ZU;2-F
Abstract
The enantiomeric. separation of several clinically used racemic drugs has b een achieved on N-(3,5-dinitrobenzoyl)-3-amino-4phenylazetidin-2-one bound to silica chiral stationary phase known as Pirkle-1J The chiral recognition mechanisms involved between the analytes and chiral stationary phase were explained using molecular modelling semi-empirical AM1 method. The results indicate that this phase is successful in resolution of beta -adrenergic bl ockers.