Artery and vein separation using susceptibility-dependent phase in contrast-enhanced MRA

In magnetic resonance angiography, contrast agents are frequently used to h elp highlight arteries over background tissue. Unfortunately, enhancing vei ns hamper the visualization of arteries when data are collected over a long period of time after the arterial phase of the contrast agent. To overcome this problem, we have developed a novel imaging and postprocessing method that is capable of eliminating veins by utilizing the susceptibility differ ence between veins and surrounding tissue. This method was applied in the p eripheral vasculature where the vessels are predominantly parallel to the m ain field and where the blood oxygen level-dependent effect is most pronoun ced. Results are presented for both long (15.8 msec) and short echo times ( 7.8 msec) and for sequential and centrally reordered acquisition schemes. T he short echo scan approach appears to be the most promising, making it pos sible to obtain good suppression of the venous signal even when the timing is not perfect or when repeat scans are necessary. (C) 2000 Wiley-Liss, Inc .