Quinoline alkaloids and other constituents of Melicope semecarpifolia withantiplatelet aggregation activity

Authors
Chen, IS Chen, HF Cheng, MJ Chang, YL Teng, CM Tsutomu, I Chen, JJ Tsai, IL
Citation
Is. Chen et al., Quinoline alkaloids and other constituents of Melicope semecarpifolia withantiplatelet aggregation activity, J NAT PROD, 64(9), 2001, pp. 1143-1147
Citations number
29
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
9
Year of publication
2001
Pages
1143 - 1147
Database
ISI
SICI code
0163-3864(200109)64:9<1143:QAAOCO>2.0.ZU;2-R
Abstract
Three new quinoline alkaloids, 2-acetylevolitrine (1), 2-acetylpteleine (2) , and semecarpifoline (3), along with 26 known compounds were isolated from the root bark of Melicope semecarpifolia. The structures of 1-3 were eluci dated by means of spectral analysis. In addition, (2S)-(-)-7,8-dimethoxypla tydesmine (4), cis-(+)-7,8-dimethoxymyrtopsine (5), and (3R)-(-)-8,9-dimeth oxygeibalansine (6) were isolated as new natural products. Several of these isolates were determined as exhibiting significant antiplatelet aggregatio n activities in vitro.