Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su

Authors
Nogawa, T Kamano, Y Yamashita, A Pettit, GR
Citation
T. Nogawa et al., Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su, J NAT PROD, 64(9), 2001, pp. 1148-1152
Citations number
15
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
9
Year of publication
2001
Pages
1148 - 1152
Database
ISI
SICI code
0163-3864(200109)64:9<1148:IASOFN>2.0.ZU;2-C
Abstract
Five new bufadienolides, 3 beta -formyloxyresibubgenin (1), 19-oxobufalin ( 2), 19-oxodesacetylcinobufagin (3), 6 alpha -hydroxycinobufagin (4), and 1 beta -hydroxybufalin (5), have been isolated together with the previously k nown bufadienolides 6-20 from the Chinese traditional drug "Ch'an Su". The structures were elucidated employing spectroscopic methods. Bufadienolides 1-5 provided significant inhibitory activity against the EB and HL-60 cance r cell lines. In addition, bufadienolide 1 was found active against the MH- 60 cancer cell line.