Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species

Authors
Uddin, MJ Kokubo, S Ueda, K Suenaga, K Uemura, D
Citation
Mj. Uddin et al., Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species, J NAT PROD, 64(9), 2001, pp. 1169-1173
Citations number
18
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
9
Year of publication
2001
Pages
1169 - 1173
Database
ISI
SICI code
0163-3864(200109)64:9<1169:HFFNCD>2.0.ZU;2-3
Abstract
Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum, sp. Their structures with absolute stereoche mistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and ex hibited potent to weak cytotoxicities against P388 cells.