The evolving management of acute right-sided heart failure in cardiac transplant recipients

Avoidance of the clinical syndrome of acute right-sided heart failure after heart transplantation is, unfortunately, not possible. Clinical experience and the literature certainly suggest that a significant factor in the succ essful management of right ventricular (RV) failure is recipient selection. Moreover, threshold hemodynamic values beyond which RV failure is certain to occur and heart transplantation is contraindicated do not exist. Nor are there values below which RV failure is always avoidable. Acute RV failure will remain a difficult and ever-present clinical syndrome in the transplan t recipient. Goals in the treatment of this clinical problem include: 1. Preserving coronary perfusion through maintenance of systemic blood pres sure. 2. Optimizing RV preload. 3. Reducing RV afterload by decreasing pulmonary vascular resistance (PVR). 4. Limiting pulmonary vasoconstriction through ventilation with high inspir ed oxygen concentrations (100% FiO(2)), increased tidal volume and optimal positive end expiratory pressure ventilation. Inhaled nitric oxide is recommended before leaving the operating room in ca ses where the initial therapies have had little impact. Intra-aortic balloo n counterpulsation is employed in patients with impaired left ventricular ( LV) function and may be of benefit in patients with RV dysfunction resultin g from ischemia, preservation injury or reperfusion injury. Optimal LV func tion reduces RV afterload and PVR. A proactive decision regarding RV assist device implantation is made before leaving the operating room and is highl y dependent upon overall hemodynamics, size and function of the ventricles as seen on transesophageal echocardiography, renal function and surgical bl eeding. Only through careful preoperative planning can this life-threatenin g condition be managed in the postoperative period. (C) 2001 by the America n College of Cardiology.