OBJECTIVES The objective of this study was to characterize temporal changes
in defibrillation thresholds (DFT's) after implantation with an active pec
toral, dual-coil transvenous lead system.
BACKGROUND Ventricular DFTs rise over time when monophasic waveforms are us
ed with nonthoracotomy lead systems. This effect is attenuated when biphasi
c waveforms are used with transvencus lead systems; however, significant in
creases in DFT still occur in a minority of patients. The long-term stabili
ty of DFTs with contemporary active pectoral lead systems is unknown.
METHODS This study was a prospective assessment of temporal changes in DFT
using a uniform testing algorithm, shock polarity and dual-coil active pect
oral lead system. Thresholds were measured at implantation, before discharg
e and at long-term follow-up (70 +/- 40 weeks) in 50 patients.
RESULTS The DFTs were 9.2 +/- 5.4 J at implantation, 8.3 +/- 5.8 J before d
ischarge and 6.9 +/- 3.6 J at long term follow-up (p < 0.01 by analysis of-
variance; p < 0.05 for long-term follow-up vs. at implantation or before di
scharge). The effect was most marked in a prespecified subgroup with high i
mplant DFTs (greater than or equal to 15 J). No patient developed an inadeq
uate safety margin (<9 J) during follow-up.
CONCLUSIONS The DFTs declined significantly after implantation with an acti
ve pectoral, dual-coil transvenous lead system, and no clinically significa
nt increases in DFT were observed. Therefore, routine defibrillation. testi
ng may not be required during the first two, years after implantation with
this lead system, in the absence of a change in the cardiac substrate or tr
eatment with antiarrhythmic drugs. (C) 2001 by the American College of Card
iology.