DEVELOPMENT OF INTRACORONARY LOCAL ADHESIVE DELIVERY TECHNIQUE

Acute coronary occlusion may occur in weak coronary atherosclerotic le sions, including dissection, ulceration or thrombus. In some cases of occlusion ''bail-out'' is performed by using recently developed New De vices. However, these have not yet completely solved the problem to th is end, we designed a new method of coronary revascularization, the In tracoronary Local Adhesive Delivery Technique, utilizing antithromboti c and absorbable adhesive injected locally into the fragile and morbid arterial wall using a drug delivery PTCA catheter more flexible than the existing New Devices. This adhesive strengthened and hardened the lesions. In this study we examined the efficacy of making an adhesive cylinder in arteries of similar size to the coronary, through acute an imal experiments using the existing clinical adhesives and drug delive ry PTCA catheters and 12 femoral arteries of adult goats. We were succ essful in forming firm tunnels along the inside of six arteries, infus ed with approximately 0.04 mi Cyanoacrylate. These funnels were observ ed with intravascular ultrasound (IVUS) imaging and evaluated microsco pically: These results suggest the feasibility of this method as a new approach for making synthetic resinous stents.