Lack of sequence variation in sporadic bovine leucosis in regions of tumour suppressor genes p53 and p16

Authors
Mayr, B Gruneis, C Brem, G Reifinger, M Schaffner, G Hochsteiner, W
Citation
B. Mayr et al., Lack of sequence variation in sporadic bovine leucosis in regions of tumour suppressor genes p53 and p16, J VET MED A, 48(6), 2001, pp. 365-371
Citations number
39
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
JOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINE
ISSN journal
0931184X → ACNP
Volume
48
Issue
6
Year of publication
2001
Pages
365 - 371
Database
ISI
SICI code
0931-184X(200108)48:6<365:LOSVIS>2.0.ZU;2-N
Abstract
Regions of the promoter and exons 5-8 of the turnout suppressor gene p53 we re analysed in 25 cases of sporadic bovine leucosis. The study included 17 cases of juvenile leucosis, five cases of adult leucosis and three cases of skin leucosis. Exon 2 of turnout suppressor gene p16 was also investigated in the same samples. No sequence variations were present in the analysed a reas of the genes. In p53, this fact represents a clear difference in compa rison with enzootic bovine leucosis. In p16, no comparative data are availa ble.