Cytopathic effects of non-syncytium-inducing and syncytium-inducing human immunodeficiency virus type 1 variants on different CD4(+)T-cell subsets are determined only by coreceptor expression

Authors
Kwa, D Vingerhoed, J Boeser-Nunnink, B Broersen, S Schuitemaker, H
Citation
D. Kwa et al., Cytopathic effects of non-syncytium-inducing and syncytium-inducing human immunodeficiency virus type 1 variants on different CD4(+)T-cell subsets are determined only by coreceptor expression, J VIROLOGY, 75(21), 2001, pp. 10455-10459
Citations number
35
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
75
Issue
21
Year of publication
2001
Pages
10455 - 10459
Database
ISI
SICI code
0022-538X(200111)75:21<10455:CEONAS>2.0.ZU;2-0
Abstract
In peripheral blood mononuclear cells, syncytium-inducing (SI) human immuno deficiency virus type 1 (HIV-1) infected and depleted all CD4(+) T cells, i ncluding naive T cells. Non-SI HIV-1 infected and depleted only the CCR5-ex pressing T-cell subset. This may explain the accelerated CD4 cell loss afte r SI conversion in vivo.