DOFETILIDE IN PATIENTS WITH LEFT-VENTRICULAR DYSFUNCTION AND EITHER HEART-FAILURE OR ACUTE MYOCARDIAL-INFARCTION - RATIONALE, DESIGN, AND PATIENT CHARACTERISTICS OF THE DIAMOND STUDIES

Authors
CAMM AJ ECHT D PRATT C MEINERTZ T MOLLER M SANDOE E BLOCHTHOMSEN PE AGNER E EGSTRUP K KOBER L TORPPEDERSEN C AURUP P FRIEDRICH T CARLSEN J VIDEBAEK J COLE D JULIAN D WHITEHEAD J ANDERSEN J FAEGERMAN O BAGGER H BAGGER JP STEINMETZ E IBSEN H HANSEN AD SKAGEN K GOTZSCHE CO NIELSEN HV BURCHARDT H SEIBAEK M MARCHANT B HANSEN S KRISTENSEN K GULDAGER T HULD P MUNSTER A ANDERSEN S PEDERSEN O SIBONI A NIELSEN T SAEKMOSE S POULSEN K LINDSKOV J AVER P ANDERSEN HH SORENSEN BK ANDERSEN HA MARKENVARD J HANSEN KN FRANDSEN F HUMBURG K JENSEN AL SOSTED U KNUDSEN BM HOLMGAARD P LYNGBORG K JACOBSEN TJ KRISTENSEN GS SYKULSKI R HILDEBRANDT P RAA D KJAERGAARD J DEPCIK H VESTERGAARD S SONDERGAARD J ORLOWITZ S OLSEN E LARSSON J HANSEN PF MAINZ H MELCHIOR T ELMING H LOEHR D JORGENSEN U BUCHWALD C ROKKEDAL J ZABEL S JORGENSEN A PLESS P BULOW M GAMMELGAARD FJ LUND B KRISTENSEN T ORLOFF P BRANDT D JENSEN SE POULSEN SH FRIIS E MYGIND L MUNK L JENSEN LE RYNNING B RALFKIAER N JORGENSEN H WINTHER M KANTERS J ABILDSTROM SZ WIEMANN O HORNUM L HERLEV KAS NELAND K HOST U GRONNING H THERKELSEN A KLARHOLT E KACZAN M VEJBYCHRISTENSEN H NIEMANN T MOURITSEN E LODAHL DB HAGGER K PEDERSEN F MADSEN J DOMINGUEZ H STEIG B BORRING M PETERSEN EL SEJERSEN H PETERSEN J MORK H JENSEN B JOHANSEN I PETERSEN M HANSEN D FROST J TOUBRO N HANSEN JF JENSEN GVH SORUM C FREDERIKSEN M SAJDIEH A SKOV N MOLGAARD S MEIER K KAISER P BRENDRUP B BLAK AK HOLMGAARD B NIELSEN M JOHANNESEN A LINDBJERG J LARSEN A WULFF B JORGENSEN L SCHEIBEL M HAAHR S LILLOR K FENGER A ASKLUND M BJERRE K GYLDENKERNE N BUHL S FELDTHAUS B METAIS I GARDE K CHRISTENSEN S RASMUSSEN B RASMUSSEN SL NIELSEN G HELO O CHRISTENSEN I LUND B GLUD T MOLLER BB GLESNER P SVENDSEN TL MADSEN H RAYMOND I LARSEN J ELIN P JENSEN BS HINTZE U HAGHFELT T VILLADSEN H THOMSEN KK GANDRUP U ROSENLUND I PAARUP L HALSE J NIELSEN I THORBALL N MOGELVANG J LARSEN I TRUESEN S KJOLLER E HEIBERG J CHRISTIANSEN K DREWES VM STENTEBJERG SE POULSEN J BUHL J LUCKOW A ANDERSEN L KJELDSEN L STENTEBJERG A KRISTENSEN H ELIASEN P LESSING M MAERKEDAL H NORHOLM C NIELSEN M GJORUP T NIELSEN H BRINCH EA SKOV JB HEMPEL H EGEDE F RASMUSSEN OB MARLEY M JENSEN IF PETERSEN J FISHER T THOMSEN NK RIGGELSEN T MARCUSSEN C BRONS M SIMONSEN E ANDERSEN J ANDERSEN B EICHORST R LAURIDSEN M ALBRECHTSEN E DORFF B ANDERSEN HB CALLESEN L DEDING A TANGO M ZEUTHEN E JOHANSEN PB NIELSEN PF MARTINSEN K VIGH L FRANDSEN K LEDERBALLE O NIELSEN HK MALCZYNSKE J RAUNGAARD B NYVAD O BENN M BERG S KRISTENSEN SD GOTZSCHE C SONDERGAARD E SONDERGAARD B LARSEN A HANSEN HT SKRIVER L WESTERGAARD M HANSEN AL BJORN M MUNKSGAARD D BRENDSTRUP C KARLSEN S CARLSEN N HOUE K DEELA C ANDERSEN H KROGSTRUP L PEDERSEN N WENDT N AGERHOLM L ANDERSEN IM JOHANSEN L LUNDBERG S NIELSEN L SNORGAARD M TVESKOV H FRIEDRICH T DALRYMPLE I WHITE S INGAMELLS A ANDREWS G HILTON C KENT C STEADMAN J HART J COE R WARWICK V SMITH K FOWLER G HOLMAN L COE A COMPTON A OAKES L WEARING A JACKSON V NELSON G MCDOWELL P EAST M MCDOWELL L BASI M DONNELLY P NITSCHMAN P SOLCA AM FARBRACE P TREBBLE A SHEPHERD S DIGHT B
Citation
Aj. Camm et al., DOFETILIDE IN PATIENTS WITH LEFT-VENTRICULAR DYSFUNCTION AND EITHER HEART-FAILURE OR ACUTE MYOCARDIAL-INFARCTION - RATIONALE, DESIGN, AND PATIENT CHARACTERISTICS OF THE DIAMOND STUDIES, Clinical cardiology, 20(8), 1997, pp. 704-710
Citations number
25
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
Clinical cardiology → ACNP
ISSN journal
01609289
Volume
20
Issue
8
Year of publication
1997
Pages
704 - 710
Database
ISI
SICI code
0160-9289(1997)20:8<704:DIPWLD>2.0.ZU;2-X
Abstract
Background: Attempts to prolong life with antiarrhythmic drugs in pati ents at increased risk of sudden cardiac death have so far been disapp ointing or inconclusive. Hypothesis: The Danish Investigations of Arrh ythmia and Mortality ON Dofetilide (DIAMOND) encompass two survival st udies testing the prophylactic use of the selective potassium-channel blocker, dofetilide, in patients at high risk of sudden death. Methods : The first study includes patients admitted to hospital with congesti ve heart failure (CI-IF), the other includes patients with acute myoca rdial infarction (MI) within the previous 7 days. In both studies pati ents must have left ventricular systolic dysfunction (ejection fractio n less than or equal to 35%) determined by echocardiography. Each of t he two studies are planned to enroll 1500 patients. Consecutive hospit alized patients with MI or CHF are screened in 37 Danish hospitals. El igible patients are randomized to receive dofetilide or matching place bo. All patients are continuously monitored by telemetry for the first 3 days of the study to detect possible arrhythmic events and to ensur e resuscitation in case of serious arrhythmias. Minimum duration of fo llow-up is 12 months. Results: Between November 1993 and July 1996, a total of 5812 consecutive patients with CHF and 8688 consecutive patie nts with MI was screened for entry. Of these, 1518 patients were inclu ded in the CHF study and 1510 patients in the MI study. Overall I-year mortality of randomized patients were 28 and 22%, respectively. Concl usion: DIAMOND will provide important data on the safety and efficacy of dofetilide in high-risk patients with left ventricular dysfunction and either CHF or MI, as well as evaluate tolerability in these popula tions.