The formation of a gastric tube after esophagectomy with ligation of the le
ft gastric artery and resection of the lesser curvature is associated with
microcirculatory changes, especially in the anastomotic region of the fundu
s. This influences the healing of the esophagogastrostomy. The presented pr
ospective protocol was designed to assess continuous tonometry as a tool to
demonstrate microcirculatory changes during gastric tube formation. in 15
patients with esophageal carcinoma, PCO2 of the gastric mucosa (PCO(2)i) wa
s measured intraoperatively during formation of a gastric tube. This was do
ne by a nasogastric tube with a silicon balloon connected to a Tonocap reci
rculating gas analyser. PCO(2)i measurements were compared for a period of
90 min before and after ligation of the left gastric artery and correlated
to the corresponding end expiratory PCO2 (PCO(2)e). In 14 of 15 patients ex
amined (93.3%), an increase of PCO(2)i after ligation of the left gastric a
rtery was demonstrated. PCO(2)i (mean +/- SD) before ligation of the left g
astric artery (87 measurements: 40.6 +/-7.5 mmHg; range, 29-67 mmHg) was si
gnificantly lower (P <0.001) compared to the mean PCO(2)i after ligation of
the left gastric artery (88 measurements: 49.1 +/- 10.2 mmHg; range, 31-79
mmHg). Continuous tonometry is a valid method to detect changes in mucosal
PCO2 during gastric tube formation and should be assessed to monitor the g
astric interposition graft during the postoperative course.