Identification and localization of M-CoREST (1A13), a mouse homologue of the human transcriptional co-repressor CoREST, in the developing mouse CNS

Authors
Tontsch, S Zach, O Bauer, HC
Citation
S. Tontsch et al., Identification and localization of M-CoREST (1A13), a mouse homologue of the human transcriptional co-repressor CoREST, in the developing mouse CNS, MECH DEVEL, 108(1-2), 2001, pp. 165-169
Citations number
16
Categorie Soggetti
Cell & Developmental Biology
Journal title
MECHANISMS OF DEVELOPMENT
ISSN journal
09254773 → ACNP
Volume
108
Issue
1-2
Year of publication
2001
Pages
165 - 169
Database
ISI
SICI code
0925-4773(200110)108:1-2<165:IALOM(>2.0.ZU;2-P
Abstract
By means of subtractive and differential hybridization techniques we have i dentified a novel murine gene (1A13) the expression of which is development ally regulated in the mouse brain. Comparison of the nucleotide and predict ed protein sequence revealed closest relationship of 1A13 to human CoREST, a transcriptional co-repressor required for regulation of neural-specific g ene expression. Thus, we will refer to 1A13 as M-CoREST. As shown by in sit u hybridization and Northern blotting, expression of M-CoREST mRNA is abund ant in neural tissue at early embryonic stages but declines significantly t owards birth, coincident with the progression of CNS maturation. (C) 2001 E lsevier Science Ireland Ltd. All rights reserved.