Niobium pentachloride catalysed ring opening of epoxides

Authors
Constantino, MG Lacerda, V Aragao, V
Citation
Mg. Constantino et al., Niobium pentachloride catalysed ring opening of epoxides, MOLECULES, 6(9), 2001, pp. 770-776
Citations number
19
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
MOLECULES
ISSN journal
14203049 → ACNP
Volume
6
Issue
9
Year of publication
2001
Pages
770 - 776
Database
ISI
SICI code
1420-3049(200109)6:9<770:NPCROO>2.0.ZU;2-7
Abstract
Epoxide ring opening is a frequently required transformation in Organic Syn thesis. In this paper we describe the application of NbCl5 for this purpose using three different substrates. Chlorohydrins, 1,2-diols, products conta ining solvent residues as well as rearrangement products are obtained, depe nding on both the substrate structure and reaction conditions. Rationalizat ions to account for some of the results are suggested.