A role for MLH3 in hereditary nonpolyposis colorectal cancer

Authors
Wu, Y Berends, MJW Sijmons, RH Mensink, RGJ Verlind, E Kooi, KA van der Sluis, T Kempinga, C van der Zee, AGJ Hollema, H Buys, CHCM Kleibeuker, JH Hofstra, RMW
Citation
Y. Wu et al., A role for MLH3 in hereditary nonpolyposis colorectal cancer, NAT GENET, 29(2), 2001, pp. 137-138
Citations number
13
Categorie Soggetti
Molecular Biology & Genetics
Journal title
NATURE GENETICS
ISSN journal
10614036 → ACNP
Volume
29
Issue
2
Year of publication
2001
Pages
137 - 138
Database
ISI
SICI code
1061-4036(200110)29:2<137:ARFMIH>2.0.ZU;2-6
Abstract
We investigated a possible role of the mismatch-repair gene MLH3 in heredit ary nonpolyposis colorectal cancer by scanning for mutations in 39 HNPCC fa milies and in 288 patients suspected of having HNPCC. We identified ten dif ferent germline MLH3 variants, one frameshift and nine missense mutations, in 12 patients suspected of HNPCC. Three of the 12 also carried a mutation in MSH6.