Photochemical rearrangement of oxaziridines and nitrones in the hexahydroindole series: A convenient synthetic route to 1-azabicyclo[5.2.0]nonan-2-ones as novel RGD mimetics

Authors
Bourguet, E Baneres, JL Girard, JP Parello, J Vidal, JP Lusinchi, X Declercq, JP
Citation
E. Bourguet et al., Photochemical rearrangement of oxaziridines and nitrones in the hexahydroindole series: A convenient synthetic route to 1-azabicyclo[5.2.0]nonan-2-ones as novel RGD mimetics, ORG LETT, 3(20), 2001, pp. 3067-3070
Citations number
32
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
20
Year of publication
2001
Pages
3067 - 3070
Database
ISI
SICI code
1523-7060(20011004)3:20<3067:PROOAN>2.0.ZU;2-Y
Abstract
GRAPHICS Photolysis of oxaziridines a or nitrones b provides a convenient synthetic route to fused bicyclic lactams c adequately substituted on both cycles A a nd B as scaffolds for mimicking conformationally constrained beta -turn pep tides as in the tripeptide RGD signaling motif of fibronectin.