H. Amil et al., Difluorinated Danishefsky's diene: A versatile C-4 building block for the fluorinated six-membered rings, ORG LETT, 3(20), 2001, pp. 3103-3105
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A Mg(0)/Me3SiCl system was found to be effective for the preparation of dif
luoro Danishefsky's dienes 2, which involves selective C-F bond cleavage of
trifluoromethyl ketones 3. Subsequent hetero Diels-Alder reactions of 2 wi
th aldehydes and imines gave a variety of fluorinated six-membered heterocy
cles.