Self-association of facially amphiphilic methylene bridged glycoluril dimers

GRAPHICS Facially amphiphilic derivatives of methylene bridged glycoluril dimers are a versatile model system for systematic studies of self-assembly in water. Thorough physical organic characterization, including analytical ultracent rifugation, a technique rarely used in synthetic self-assembly studies, all ows us to conclude that this class of molecules undergoes hydrophobically d riven self-association to yield tightly associated discrete dimeric assembl ies.