Micromonospolides A-C, new macrolides from Micromonospora sp.

Authors
Ohta, E Kubota, NK Ohta, S Suzuki, M Ogawa, T Yamasaki, A Ikegami, S
Citation
E. Ohta et al., Micromonospolides A-C, new macrolides from Micromonospora sp., TETRAHEDRON, 57(40), 2001, pp. 8463-8467
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
40
Year of publication
2001
Pages
8463 - 8467
Database
ISI
SICI code
0040-4020(20011001)57:40<8463:MANMFM>2.0.ZU;2-V
Abstract
Three new macrolides, micromonospolides A-C, have been isolated from a new species of the genus Micromonospora and their structures were elucidated to be bafilomycin-type macrolides which have a 16-membered lactone ring on th e basis of spectroscopic data. Micromonospolides A-C inhibited gastrulation of starfish embryos at minimum inhibitory concentrations of 0.010, 0.011 a nd 1.6 mug mL(-1) respectively. (C) 2001 Elsevier Science Ltd. All rights r eserved.