Total synthesis of epothilone A

Authors
Hindupur, RM Panicker, B Valluri, M Avery, MA
Citation
Rm. Hindupur et al., Total synthesis of epothilone A, TETRAHEDR L, 42(42), 2001, pp. 7341-7344
Citations number
24
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
42
Year of publication
2001
Pages
7341 - 7344
Database
ISI
SICI code
0040-4039(20011015)42:42<7341:TSOEA>2.0.ZU;2-H
Abstract
A convergent total synthesis of epothilone A (1) is described. The key step s are diastereoselective aldol condensation Of aldehyde 3 to form the C-6 C -7 bond: macrolactonization and Wadsworth-Emmons reaction of methyl ketone with phosphonate reagent 5. (C) 2001 Elsevier Science Ltd. All rights reser ved.