On the use of phosphine-free PdCl2(SEt2)(2) complex as catalyst precursor for the Heck reaction

A simple and efficient experimental protocol has been developed for the cat alytic arylation of alkenes by the air and water stable. and phosphine-free compound PdCl2(SEt2)(2) associated vith tetrabutyl ammonium bromide. Using this catalytic protocol, aryl iodides and bromides. and electron-poor aryl chlorides Lire coupled with n-butylacrylate and styrene under relatively m ild reaction conditions with high catalytic activity. Reaction vessel ultra -trace amounts (ppt) of this Pd precursor promotes the ccupling of iodo ben zene with n-butylacrylate with turnover numbers (mol product mol Pd) Lip to 10 degrees. (C) 2001 Elsevier Science Lid. All rights reserved.