AUTOMATED ARRAY TECHNOLOGIES FOR GENE-EXPRESSION PROFILING

Array-based technologies are poised to revolutionize the application o f genomic research to drug discovery. These highly parallel techniques are able to simultaneously analyze up to hundreds of thousands of ele ments, each arrayed al high density across the surface of solid suppor ts. This review provides a summary of some recently established array- based technologies for gene expression profiling. As an example, the a uthors highlight their experience with OligoFingerprinting - a technol ogy platform that enables the generation of complete profiles of gene expression patterns - and compare it with conventional high-throughput cDNA sequencing.