Array-based technologies are poised to revolutionize the application o
f genomic research to drug discovery. These highly parallel techniques
are able to simultaneously analyze up to hundreds of thousands of ele
ments, each arrayed al high density across the surface of solid suppor
ts. This review provides a summary of some recently established array-
based technologies for gene expression profiling. As an example, the a
uthors highlight their experience with OligoFingerprinting - a technol
ogy platform that enables the generation of complete profiles of gene
expression patterns - and compare it with conventional high-throughput
cDNA sequencing.