Antimicrobial activity studies of the metal complexes derived from substituted cyclobutane substituted thiazole Schiff base ligands

Two novel bidentate Schiff base ligands derived from 4-(1-methyl-1-mesitylc yclobutane-3-yl)-2-aminothiazole (LH) have been prepared and characterized by elemental analyses, i.r., C-13- and H-1-n.m.r. spectra, u.v.-vis. and ma gnetic susceptibility measurements. The complexes are mononuclear. Antimicr obial activities of the ligands and their complexes have been tested: Bacil lus megaterium DSM 32, Candida albicans FMC 17, Enterobacter aeroginosa CCM 2531, Escherichia coli ATCC 25922, Listeria monocytogenes SCOTTA, Micrococ cus luteus LA 2971, Proteus vulgaris FMC 11, Pseudomonas aeruginosa DSM 500 71, Saccharomyces cerevisiae FMC 16 and Staphylococcus aureus COWAN I. The thermal properties of the ligands and their complexes have been studied by t.g.a.