In prokaryotic cells, protein synthesis commences on nascent messenger RNAs
while they are still being synthesized on the DNA template. The eukaryotic
nuclear envelope spatially segregates protein synthesis away from the geno
me and messenger RNA production-this being thought to be a defining feature
of the Eukarya. New results suggest that the eukaryotic 'standard model' m
ight be an oversimplification. How good is the evidence for translation in
the cell nucleus, and, if sound, where do the new findings take us?