The dual role of CTLA-4 in Leishmania infection

Authors
Gomes, NA DosReis, GA
Citation
Na. Gomes et Ga. Dosreis, The dual role of CTLA-4 in Leishmania infection, TRENDS PARA, 17(10), 2001, pp. 487-491
Citations number
52
Categorie Soggetti
Microbiology
Journal title
TRENDS IN PARASITOLOGY
ISSN journal
14714922 → ACNP
Volume
17
Issue
10
Year of publication
2001
Pages
487 - 491
Database
ISI
SICI code
1471-4922(200110)17:10<487:TDROCI>2.0.ZU;2-R
Abstract
The role of CTLA-4 in inducing the production of transforming growth factor beta (TGF-beta) from T cells during a Leishmania infection has only recent ly been recognized. However, CTLA-4 and TGF-beta affect T helper cells diff erently, depending on the maturation. This review discusses the data obtain ed from different experimental models and demonstrates that CTLA-4 is a tar get molecule for vaccination and therapy against leishmaniasis.