Biliary anastomotic complications in 400 living related liver transplantations

The purpose of this study was to evaluate the cause and outcome of biliary anastomotic complications occurring after living related liver transplantat ion (LRLT). A database of 391 patients undergoing 400 LRLT from June 1990 t o August 1998 was reviewed. The overall incidence of biliary anastomotic co mplications was 18.2% (71 patients). There were 45 bile leaks, 35 anastomot ic strictures, and the bile duct was ligated inadvertently in 3 cases. Univ ariative analysis revealed that the manner of stent usage, intrapulmonary s hunting, and gender of recipients were significant risk factors for leakage . Anastomotic leaks', cytomegalovirus infection, hepatic artery complicatio ns, and gender or recipients were significant risk factors for stricture. I n pediatric patients older than 2 years old, ABO blood type compatibility w as another risk factor for leakage and stricture. Choice of stent usage and earlier transplantation for patients with intrapulmonary shunting should r educe the rate of biliary leaks, and prophylaxis of leaks for patients with intrapulmonary shunting, and minimizing hepatic artery complications shoul d reduce the rate of biliary stricture after LRLT. Avoidance of ABO-incompa tible donors or innovative immunosuppression in ABO-incompatible transplant ation should be considered in children.