Synthesis and antiviral activity of 2 '-deoxy-2 '-fluoro-L-arabinofuranosyl 1,2,3-triazole derivatives

Authors
Citation
S. Olgen et Ck. Chu, Synthesis and antiviral activity of 2 '-deoxy-2 '-fluoro-L-arabinofuranosyl 1,2,3-triazole derivatives, Z NATURFO B, 56(8), 2001, pp. 804-811
Citations number
21
Categorie Soggetti
Chemistry
Journal title
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
ISSN journal
09320776 → ACNP
Volume
56
Issue
8
Year of publication
2001
Pages
804 - 811
Database
ISI
SICI code
0932-0776(200108)56:8<804:SAAAO2>2.0.ZU;2-J
Abstract
The title compounds were prepared by building up the triazole ring at the a nomeric position via the glycosyl azides 5 a,b. The anomeric configurations of these nucleosides were assigned by using H-1, C-13 and NOESY NMR spectr oscopy. The synthesized nucleosides were evaluated against HIV-1 and HBV.