Integrating clinical and basic sciences throughout the medical school curri
culum has become a major objective of various innovations in medical educat
ion. While early clinical exposure has evolved as an efficient means of int
roducing clinical studies in the preclinical years, interdisciplinary integ
ration of basic sciences during the clinical years remains a challenge. The
authors describe their three years of experience with an interdisciplinary
course designed to demonstrate the continuum of medical information from t
he clinic to the basic sciences. In this course, sixth-year medical student
s are required to choose one of three to four different one-week programs,
each of which requires them to conduct an in-depth investigation of a defin
ed clinical topic. Program coordinators are encouraged to work in clinician
-basic scientist teams and to use a variety of teaching methods, with an em
phasis on tutored individual and group learning based on critical readings
of original papers. Coordinators are also encouraged to enable graduate res
earch students to participate. From 1998 to 2000, students participated in
nine programs, seven of which were coordinated by interdisciplinary teams.
Several clinical and basic science disciplines were represented in each pro
gram, and various teaching methods were used. Graduate students participate
d in two of the programs. Evaluation of the programs (a debriefing discussi
on as well as short written evaluations) indicated moderate to good achieve
ment of the course objectives.