(+)-N-{4-[(1S,2S)-2-(Dimethylamino)-1-(1H-imidazol-1-yl)propyl]phenyl}-2-benzothiazolamine

Citation
Om. Peeters et al., (+)-N-{4-[(1S,2S)-2-(Dimethylamino)-1-(1H-imidazol-1-yl)propyl]phenyl}-2-benzothiazolamine, ACT CRYST E, 57, 2001, pp. O723-O724
Citations number
9
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE
ISSN journal
16005368 → ACNP
Volume
57
Year of publication
2001
Part
8
Pages
O723 - O724
Database
ISI
SICI code
1600-5368(200108)57:<O723:(>2.0.ZU;2-R
Abstract
The metabolism of all-trans-retinoic acid is mediated by a cytochrome depen dent P-450 system. The title compound, C21H23N5S, is an inhibitor of the P- 450 system. Two planar rings connected via a central CH group form a dihedr al angle of 80.2 (1)degrees; the planar systems connected through an NH gro up form a dihedral angle of 37.12 (8)degrees. The N-H . . .N hydrogen bonds link the molecules of the title compound into infinite chains stretching a long the c direction.