Experimental data on the production of kaons and antikaons in heavy-ion col
lisions at relativistic energies are presented and discussed with respect t
o in-medium effects. The K-/K+ ratios measured in nucleus-nucleus collision
s are 1-2 orders of magnitude larger than in proton-proton collisions. The
azimuthal angle distributions of K+ mesons indicate a repulsive kaon-nucleo
n potential. Microscopic transport calculations consistently explain both t
he yields and the emission patterns of kaons and antikaons when assuming th
at their properties are modified in dense nuclear matter. The K+ production
excitation functions measured in light and heavy collision systems provide
evidence for a soft nuclear equation-of-state.