Time to discontinuation of the first highly active antiretroviral therapy regimen: a comparison between protease inhibitor- and non-nucleoside reverse transcriptase inhibitor-containing regimens

Data from a cohort of HIV-positive individuals who were antiretroviral naiv e at enrolment were analysed to estimate the probability of discontinuing t he first highly active antiretroviral therapy (HAART) regimen, comparing pr otease inhibitor and non-nucleoside reverse transcriptase- containing regim ens. Of the 2002 individuals who began HAART, 857 (42.8%) discontinued thei r first regimen. No statistically significant difference was found in the t ime to discontinuation by specific type of regimen, either when considered overall or by specific reason.