EVALUATION OF MEMBRANES OF COPOLYPEPTIDE OF GAMMA-BENZYL L-GLUTAMATE AND L-GLUTAMIC ACID FOR THE PERMEABILITY OF ANTICANCER DRUGS

Authors
HE WD FANG YE SHI TY
Citation
Wd. He et al., EVALUATION OF MEMBRANES OF COPOLYPEPTIDE OF GAMMA-BENZYL L-GLUTAMATE AND L-GLUTAMIC ACID FOR THE PERMEABILITY OF ANTICANCER DRUGS, Journal of membrane science, 130(1-2), 1997, pp. 17-21
Citations number
7
Categorie Soggetti
Engineering, Chemical","Polymer Sciences
Journal title
Journal of membrane science → ACNP
ISSN journal
03767388
Volume
130
Issue
1-2
Year of publication
1997
Pages
17 - 21
Database
ISI
SICI code
0376-7388(1997)130:1-2<17:EOMOCO>2.0.ZU;2-W
Abstract
The membranes of poly(gamma-benzyl L-glutamate-co-L-glutamic acid) [P( BLG-LGA)] were prepared by saponification of poly(gamma-benzyl L-gluta mate) (PBLG) membranes. The permeation of two anticancer drugs, 5-fluo ro-uracil (5-fu) and 2-hydroxyethyl-oxy-methyl-5-fluoro-uracil (2-HEOM -5-Fu), through these membranes was studied. The results showed a shar p increase in permeability of the copolymer membranes compared to the PBLG membranes.