Cheilitis granulomatosa Miescher: Treatment with clofazimine and review ofthe literature

Cheilitis granulomatosa Miescher is a rare condition of unknown cause chara cterized by intermittent lip swelling that gradually persists and causes co smetic deformity. We report the case of a young woman with cheilitis granul omatosa as a monosymptomatic manifestation of Melkersson-Rosenthal syndrome successfully treated by the antileprosy agent clofazimine. and propose clo fazimine as an alternative treatment in cases refractory to corticosteroids . The differential diagnosis and cur-rent methods of treatment are summariz ed, and the literature is reviewed and discussed.