Fenoldopam in the prevention of contrast media-induced acute renal failure

OBJECTIVE: To examine the role of fenoldopam in prevention of contrast medi a-induced acute renal failure (ARF). DATA SOURCES: A literature search of MEDLINE (from 1966 to October 2000) wa s performed using the following title search terms: fenoldopam, contrast, a nd renal failure. STUDY SELECTION: English-language human studies, abstracts, and pertinent a nimal data were reviewed. DATA SYNTHESIS: Small trials using animals with artificially induced ARF re ceiving fenoldopam demonstrated improvement in renal function. Preliminary trials in healthy humans have also demonstrated similar results using doses not affecting systemic blood pressure. CONCLUSIONS: Fenoldopam may have a role in the management of ARF induced by contrast dye. However, due to the lack of a large-scale study, it cannot b e routinely recommended.