The HMMTOP transmembrane topology prediction server

The HMMTOP transmembrane topology prediction server predicts both the local ization of helical transmembrane segments and the topology of transmembrane proteins. Recently, several improvements have been introduced to the origi nal method. Now, the user is allowed to submit additional information about segment localization to enhance the prediction power. This option improves the prediction accuracy as well as helps the interpretation of experimenta l results, i.e. in epitope insertion experiments.