A series of lactosaminylated oligosaccharides found in mucin type O-glycans
was synthesized using a generalized block strategy. The synthesis involved
the addition of a protected lactosamine donor to a partially protected T-d
isaccharide derivative. The nonreducing galactose residues of the deblocked
oligosaccharide products could be removed by beta -galactosidase from jack
bean to produce the corresponding GlcNAc terminated compounds. A series of
tri- to hexasaccharides was thus efficiently produced. (C) 2001 Elsevier S
cience Ltd. All rights reserved.