Synthesis, characterisation and antiamoebic activity of new thiophene-2-carboxaldehyde thiosemicarbazone derivatives and their cyclooctadiene Ru(II) complexes

Authors
Shailendra,"Bharti, N Garza, MTG Cruz-Vega, DE Garza, JC Saleem, K Naqvi, F Azam, A
Citation
N. Shailendra,"bharti et al., Synthesis, characterisation and antiamoebic activity of new thiophene-2-carboxaldehyde thiosemicarbazone derivatives and their cyclooctadiene Ru(II) complexes, BIOORG MED, 11(20), 2001, pp. 2675-2678
Citations number
26
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
20
Year of publication
2001
Pages
2675 - 2678
Database
ISI
SICI code
0960-894X(20011022)11:20<2675:SCAAAO>2.0.ZU;2-4
Abstract
Reaction of new thiosemicarbazones. (1-4) derived from thiophene-2-carboxal dehyde and cycloalkylaminothiocarbonylhydrazine with [Ru(eta (4)-C8H12)(CH3 CN)(2)Cl-2] leads to form complexes (1a-4a) of the typed [Ru(eta (4)-C8H12) (TSC)Cl-2] (where TSC=thiosemicarbazone). All the compounds have been chara cterised by elemental analysis, IR, H-1 NMR, electronic spectra and thermog ravimetric analysis. It is concluded that the thionic sulphur and the azome thine nitrogen atom of the ligands are bonded to the metal ion. In vitro an tiamoebic screening against (HK-9) strain of Entamoeba histolytica indicate d that the Ru(II) complexes of thiophene-2-carboxaldehyde thiosemicarbazone s were found more active than the thiosemicarbazones. (C) 2001 Elsevier Sci ence Ltd. All rights reserved.