N,N '-bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents

Authors
Huang, TL Tao, B Quarshie, Y Queener, SF Donkor, IO
Citation
Tl. Huang et al., N,N '-bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents, BIOORG MED, 11(20), 2001, pp. 2679-2681
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
20
Year of publication
2001
Pages
2679 - 2681
Database
ISI
SICI code
0960-894X(20011022)11:20<2679:N'AAC>2.0.ZU;2-4
Abstract
The synthesis, anti-Pneumocystis carinii activity and DNA binding propertie s of eight new N,N'-bis[4-(N-alkylamidino)phenyl]homopiperazines are report ed. Compounds 2 and 8 were the most potent and caused about 70% inhibition of Pneumocystis carinii growth in a cell culture model at 1 muM concentrati ons. (C) 2001 Elsevier Science Ltd. All rights reserved.