A series of alpha -amino-beta -sulphone hydroxamates was prepared and evalu
ated for potency versus MMP-13 and selectivity versus MMP-1. Various substi
tuents were employed on the alpha -amino group (P-1 position), as well as d
ifferent groups attached to the sulphone group extending into P-1'. Low nan
omolar potency was obtained for MMP-13 with selectivity versus MMP-1 of > 1
000x for a number of analogues. (C) 2001 Elsevier Science Ltd. All rights r
eserved.