Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase

Authors
Tillekeratne, LMV Sherette, A Grossman, P Hupe, L Hupe, D Hudson, RA
Citation
Lmv. Tillekeratne et al., Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase, BIOORG MED, 11(20), 2001, pp. 2763-2767
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
20
Year of publication
2001
Pages
2763 - 2767
Database
ISI
SICI code
0960-894X(20011022)11:20<2763:SCIOHR>2.0.ZU;2-G
Abstract
Systematic simplification of the molecular structures of epicatechin gallat e and epigallocatechin gallate to determine the minimum structural characte ristics necessary for HIV-1 reverse transcriptase inhibition in vitro resul ted in several compounds that strongly inhibited the native as well as the A17 double mutant (KI03N Y181C) enzyme, which is normally insensitive to mo st known nonnucleoside inhibitors. (C) 2001 Elsevier Science Ltd. All right s reserved.