Successful non-myeloablative allogeneic peripheral blood stem cell transplantation (PBSCT) for Waldenstrom's macroglobulinemia with severe pancytopenia

We report a 62-year-old male who underwent non-myeloablative allogeneic per ipheral blood stem cell transplantation (PBSCT) because of his life-threate ning severe pancytopenia due to refractory Waldenstrom's macroglobulinemia. This therapy was performed safely and he made a marked recovery from his c ytopenia that had not been improved with any other therapy. Bone marrow asp irates showed post-transplant mixed chimerism during engraftment, and becam e completely donor-derived after a series of GVHD symptoms, without subsequ ent donor lymphocyte infusion. Our results suggest that non-myeloablative a llogeneic PBSCT could be a good alternative for patients suffering from mul tidrug resistant Waldenstrdm's macroglobulinemia.