Synthesis and biological activity of 3,7-anhydro-2,4-dideoxy-4-[(R)-3-hydroxytetradecanoylamino]-6-O-phosphono-5-O-[(R)-3-(tetradecanoyloxy)tetradecanoyl]-D-glycero-D-ido-octonic acid derivatives

Authors
Wakabayashi, T Shiozaki, M Kanai, S Kurakata, S
Citation
T. Wakabayashi et al., Synthesis and biological activity of 3,7-anhydro-2,4-dideoxy-4-[(R)-3-hydroxytetradecanoylamino]-6-O-phosphono-5-O-[(R)-3-(tetradecanoyloxy)tetradecanoyl]-D-glycero-D-ido-octonic acid derivatives, B CHEM S J, 74(9), 2001, pp. 1661-1665
Citations number
20
Categorie Soggetti
Chemistry
Journal title
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
ISSN journal
00092673 → ACNP
Volume
74
Issue
9
Year of publication
2001
Pages
1661 - 1665
Database
ISI
SICI code
0009-2673(200109)74:9<1661:SABAO3>2.0.ZU;2-I
Abstract
D-Glucosaminylacetic acid derivatives (10, 11 and 12) of GLA-60 were synthe sized to investigate the LPS-antagonistic activity toward human monoblastic U937 cells. Compounds 10 and 11 show weak LPS-antagonistic activity, but 1 2 shows both LPS-antagonistic and -agonistic activities, depending on the c oncentration.