Elevated levels of high-mobility-group chromosomal proteins, HMGA1, in murine skin carcinoma

The high-mobility-group, HMGA1 (formerly HMGI(Y)) chromosomal proteins are known to be involved in gene regulation and their high expression is associ ated with neoplastic transformation of cells and metastatic tumor progressi on. Here, we present our results on the expression of HMGA1 in murine skin carcinoma as detected by acid-urea electrophoresis, reverse-phase high-perf ormance liquid chromatography and Western blot. The enhanced expression of HMGA1 proteins directly correlates with the extent of cellular atypia and n eoplastic changes noticed in the histopathology of tumor and suggest a pote ntial use of these proteins as marker for determining the grade of skin tum or. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.