The transradial approach (TRA) has been used for diagnostic and interventio
nal cardiology. It has not previously been determined how many times the sa
me radial artery can be cannulated without complications. A total of 812 pa
tients (502 men and 310 women) underwent angiography or angioplasty via the
TRA between 1997 and 1999 at our institution with a total of 1,438 procedu
res. Sheaths were 5 (55%) or 6 Fr (45%). Dropout rates of 3.5% and 7.9% wer
e found at the second TRA attempt in the men and the women, respectively. O
f the 62 TRA failures, 56 (90%) were due to narrowing or occlusion of the r
adial artery after the previous TRA procedure. A third TRA procedure was po
ssible in 90% of the men and 80% of the women. A fifth TRA procedure was po
ssible in 70% of the men and 50% of the women. The dropout rates for TRA in
creased as successive punctures were performed. This was primarily due to v
essel narrowing and occlusion occurring as a function of multiple punctures
. (C) 2001 Wiley-Liss, Inc.